GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs703842 | 1 | rs703842 | chr12:58162739 | FAM119B | chr12:58166383-58176323:+ | -0.41 | -5.65 | 1.64E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs703842 | chr12:58162739 | TSFM | chr12:58176536-58191367:+ | 0.3 | 5.39 | 5.23E-7 | Multiple sclerosis |
| THYM | cis | rs6477998 | 1 | rs7038769 | chr9:116007583 | CDC26 | chr9:116029290-116037869:- | -0.36 | -5.77 | 9.96E-8 | Hematology traits |
| THYM | cis | rs1875620 | 1 | rs7038956 | chr9:91553712 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs7044951 | chr9:91564637 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.69 | 8.99E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs7047321 | chr9:91555547 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs877636 | 1 | rs705696 | chr12:56480648 | RPS26 | chr12:56435686-56438005:+ | 0.96 | 10.16 | 7.65E-17 | Cognitive function |
| THYM | cis | rs7072122 | 1 | rs7072122 | chr10:45034672 | ZNF22 | chr10:45496273-45500776:+ | 0.64 | 5.71 | 1.28E-7 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072216 | 1 | rs7072216 | chr10:100156853 | PYROXD2 | chr10:100143323-100174978:- | 0.78 | 12.99 | 8.8E-23 | Metabolite levels |
| THYM | cis | rs12780845 | 1 | rs7072634 | chr10:17240918 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.71 | 8.37E-6 | Homocysteine levels |
| THYM | cis | rs12220898 | 1 | rs7074999 | chr10:50602997 | PGBD3 | chr10:50723247-50747584:- | -0.69 | -4.44 | 2.45E-5 | Inflammatory biomarkers |
| THYM | cis | rs12780845 | 1 | rs7082376 | chr10:17232223 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.71 | 8.37E-6 | Homocysteine levels |
| THYM | cis | rs12780845 | 1 | rs7084476 | chr10:17211383 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.85 | 4.79E-6 | Homocysteine levels |
| THYM | cis | rs7072122 | 1 | rs7086617 | chr10:45007607 | ZNF22 | chr10:45496273-45500776:+ | 0.58 | 5.32 | 7.02E-7 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs8078723 | 1 | rs709592 | chr17:38175553 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.35 | 3.97E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |